Personal Statement
You can find the lab on bluesky at emmottlab@bsky.social.

The lab's goal is the use and development of proteomic methods to study RNA virus replication and virus-host interactions, and in particular, the use and development of single-cell and other proteomic methods to aid in this research. The lab primarily works on (murine) norovirus and coronaviruses including SARS-CoV-2. We are particularly interested in the role viral and cellular substrates of viral proteases play in the viral life cycle, for example cellular substrates of the SARS-CoV-2 proteases Meyer et al. 2021, and the role of precursor forms of the norovirus protease during infection (Emmott et al. 2019).

We also apply our proteomics expertise to support other groups working on different questions. Currently we are part of two LifeArc/CF Trust consortia working with clinical samples from people living with cystic fibrosis - a long-running collaboration with Manchester and Alder Hey, and a collaboration with Chulalongkorn/LSTM on snake venom proteomics.

We are very grateful to our funders. Since November 2019, the lab has been supported by ~£4m funding as PI and a further ~£16m of collaborative funding.

Current lab members:
PhD Students:
Charlotte Duncan
Jessica Coomber
Patchara Sittishivapark
Markella Loi
Henry Steele-Childe
Trinity Bakshi

PDRAs:
Leandro Neves
Frazer Buchanan
Rebee Penrice-Randal
Max Erdmann
Rosie Maher

Consulting:
Ed can consult on:
- single-cell proteomics
- mass spectrometry-based proteomics
- virology, especially calicivirus (e.g. norovirus)/coronavirus biology

Research Overview
My lab is interested in the study of virus-host interactions and virus replication for RNA viruses, especially where the replication of these viruses is governed by proteolytic cleavage and the impact of viral proteases on the host cell. These include the coronaviruses and noroviruses. We develop and apply mass spectrometry-based proteomic methods in support of this research. An example would be the development and application of single-cell proteomics by mass spectrometry methods, having helped develop the SCoPE2 carrier/reference approach being adopted internationally across different single-cell proteomics approaches. The ultimate goal of our research is to identify and characterize virus-host interactions and replication mechanisms that can be targeted to inhibit virus replication as an antiviral strategy.