Personal Statement
Dr Carl Sheridan is the academic education lead for the Department of Eye and Vision Sciences at the University of Liverpool. He is an ocular cell biologist with over 30 years of research experience in eye health and disease. His work focuses on understanding cellular mechanisms that drive glaucoma and ocular wound healing.
Carl’s current research investigates the trabecular meshwork and its role in primary open-angle glaucoma (POAG). He develops advanced 3D in vitro models and organ culture systems to study disease progression. His team explores stem cell-based strategies and biomaterials to regenerate the outflow pathway and restore intraocular pressure control.
Earlier in his career, Carl pioneered research into wound healing after glaucoma surgery and retinal pigment epithelium (RPE) biology. His fellowship work helped establish cell transplantation concepts that underpin current regenerative medicine approaches. He continues to integrate tissue engineering and bioengineering into ocular research.
Carl’s ethos is rooted in a multidisciplinary team approach to solving complex research challenges. He collaborates across biomedicine, bioengineering, and clinical science to translate laboratory findings into therapies that prevent sight loss.
Carl welcomes PhD applications in glaucoma research, wound healing, tissue engineering, and regenerative medicine.

Research Overview
Research Overview
Dr Carl Sheridan’s research addresses cellular mechanisms that drive glaucoma and ocular wound healing. His work focuses on trabecular meshwork dysfunction in primary open-angle glaucoma, developing advanced 3D in vitro models and organ culture systems to study disease progression. He explores stem cell-based therapies and biomaterials to regenerate the outflow pathway and restore intraocular pressure control.
Carl also investigates retinal wound healing in conditions such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). This research is underpinned by retinal pigment epithelium biology and aims to inform regenerative medicine strategies for vision restoration.
His studies combine cell culture, imaging, and omics technologies, supported by collaborations in biomedicine and bioengineering. The goal is to translate laboratory findings into therapies that prevent sight loss.

Research Interests
1. Glaucoma and Trabecular Meshwork Biology
Carl studies the cellular and molecular mechanisms underlying trabecular meshwork dysfunction in primary open-angle glaucoma. His team develops 3D in vitro models and organ culture systems to replicate disease conditions. Research includes stem cell-based therapies and biomaterial scaffolds to regenerate trabecular meshwork and restore aqueous outflow.
2. Retinal Wound Healing and RPE Cell Biology
This area focuses on wound healing processes in retinal diseases such as AMD and PVR. Carl investigates how RPE cells respond to injury and degeneration, aiming to develop cell-based and tissue-engineered solutions for retinal repair.
3. Tissue Engineering and Regenerative Medicine
Carl integrates biomaterials, stem cells, and tissue engineering to design transplantable cell layers and ocular models. These approaches support regenerative strategies for glaucoma and retinal disorders, bridging laboratory research and clinical application.

PhD Recruitment areas
glaucoma research, trabecular meshwork, primary open-angle glaucoma, retinal pigment epithelium, ocular wound healing, AMD, PVR, stem cell therapy, induced pluripotent stem cells (iPSCs), tissue engineering, regenerative medicine, biomaterials, ocular drug delivery, vision science, ocular cell biology, ophthalmology, bioengineering, biomedicine, translational eye research, PhD in glaucoma, PhD in regenerative medicine, PhD in tissue engineering, PhD in bioengineering, PhD in biomedicine, postgraduate research in ocular disease.