The focus of his research programme is to improve the lives of children with cystic fibrosis (CF). This work has evolved through, 1) his interest in evidence-based medicine (Editor of the CF and Genetics Disorders Cochrane Review Group (CRG) and author on numberous reviews), 2) his work on diagnostics, in particular newborn screening for CF (European Lead for CF Newborn Screening Working Group) and 3) his interst in clinical trials and pragmatic clinical outcome measure. KWS is well respect in the field as a clinical academic with a forward thinking approach to patient care and is regularly invited to speak at international meetins and contribute to guidelines on care, through both research activities and advocacy of CF screening. KWS runs the Liverpool Paediatric CF Research Programme, which has five active work packages.