Personal Statement
The biochemical and mechanical properties of the tumour microenvironment drive cancer invasion and metastasis. The major goals of my lab are to understand how tumour and stromal cells sense and interpret their extracellular microenvironment and how these mechanisms drive cancer progression and the response to targeted molecular therapeutics. We employ inter-disciplinary approaches incorporating proteomics, genomics, biophysical techniques and multi-modal live-cell imaging to dissect the impact of adhesion and growth factor receptor crosstalk mechanisms on cancer cell invasion, tumour-stromal interaction and drug resistance mechanisms.

We also have strong interests in how adhesion and growth factor receptor signalling networks and trafficking are dynamically integrated, spatially and temporally, to control mechanical force transmission, cell migration, wound healing and stem cell function and are dysregulated in fibrotic disease.